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Scientists find antimalarial drug may be repurposed to treat Zika
In their search for a possible treatment for Zika virus infection, a team of Indian researchers has identified a viral protein that can be targeted by an already available antimalarial drug, hydroxychloroquine (HCQ).
Researchers hit upon the protein when they conducted a high throughput virtual screening of a library of drugs approved by America’s Food and Drugs Authority. Out of 1861 compounds in the library, five including HCQ appeared to be possible candidates for the treatment of Zika virus. It has also been found that HCQ limits the Zika virus transmission from mother to fetus.
The study was conducted by researchers at the Indian Institute of Technology, Mandi, Alagappa University in Karaikudi, Tamil Nadu and Washington University at St. Louis.
Hopefully we are close to finding a potential drug against Zika. We have successfully identified the target protein on which HCQ acts. Since it is an FDA approved drug our journey for validation may be less tedious and we can go for preclinical trials faster,” said Dr. Rajanish Giri, a researcher at IIT Mandi, while speaking with India Science Wire.
“Repurposing approved drugs can be an efficient method to identify drug compounds, which may be capable of activating or inhibiting new targets. This approach has some advantageous features, including reduced development time and expense and improved safety” he added.
Zika gets transmitted by the bite of an infected mosquito from the Aedes genus, mainly Aedes aegypti. This is the same mosquito that transmits dengue, chikungunya and yellow fever.
This virus infection during pregnancy is a cause of microcephaly (reduced head size) and other congenital abnormalities in developing fetus and newborns. Zika infection in pregnancy also results in pregnancy like fetal loss, stillbirth and preterm birth. Further, it is known to be associated with certain neurological disorders like Guillain-Barré syndrome in adults and cause problems like neuropathy and myelitis, particularly in older children and adults. The rapid spread of this virus in recent years has led to a surge in efforts to find an effective therapeutic intervention.
The team of researchers includes Dr.Rajanish Giri from IIT Mandi, Prof. Indira U. Mysorekar from Washington University and Prof. Sanjeev Kumar Singh from Alagappa University. A paper on the work has been recently been published in journal ACS Omega.
Sept 27th 2017n in
Seema KumarFollowSeema KumarVice President, Innovation, Global Health, and Policy CommunicationDr. Celina Maria Turchi Martelli: The Brazilian disease hunter led a team that raced the clock to establish the link between the Zika virus and microcephaly in infantsI wrote recently about Dr. Paul Janssen, a prolific researcher who frequently asked, “What’s new?” and reminded his teams that urgency in the search for treatments and cures is paramount. He put it simply: “Patients are waiting.”When it comes to stemming the tide of epidemic diseases, which can spread with a sneeze, a handshake or the bite of a mosquito, that urgency is even more critical. Mothers, fathers and entire communities worry about how to protect their children and each other. Researchers like Dr. Celina Maria Turchi Martelli, one of Brazil’s leading epidemiologists, know that there is only so much time to find a solution. Each passing day means that exponentially more people could become carriers or fall ill.In early 2016, Dr. Turchi found herself at the center of a terrifying medical mystery. Doctors were reporting a surprising number of cases of microcephaly, or extremely small heads, in infants born in Recife, the capital of the northeastern state of Pernambuco. Dr. Turchi was working at the Oswaldo Cruz Foundation there when she received a call from Brazil’s ministry of health, asking her to investigate.Visiting area hospitals, she discovered an unfolding tragedy: Baby after baby born with flat, foreshortened foreheads, reflecting serious brain damage. “I felt like I was in a horror movie,” Dr. Turchi told The Guardian. She recounted to The New York Times,“The pediatricians were saying, ‘We’ve never seen anything like this.’”Medical experts had floated, and discarded, many possible causes, but one that piqued Dr. Turchi’s interest was the mosquito-borne Zika virus, which had swept through Brazil, causing thousands of people to suffer fever, joint pains and rashes.While some of the mothers in Recife recalled having suffered those symptoms during their pregnancies, the babies born with microcephaly all tested negative for the virus.Dr. Turchi knew she didn’t have a moment to waste. To solve this medical mystery, she must convince leading researchers from around the world and across disciplines to drop everything, set up shop in Recife and work together, day and night, to find an answer.Using her “hard” medical-expertise skills to identify the needs, and her “soft” networking skills to tap the talent, she recruited the best infectious-disease specialists, epidemiologists, pediatricians, neurologists and reproductive biologists, to form the Microcephaly Epidemic Research Group.Dr. Turchi had members of the disease-hunting team staying in her own apartment in Recife, and the determined crew was fueled by meals of rice, beans and chicken cooked by a research assistant’s mother. Their big break came when a researcher discovered the Zika virus in the amniotic fluid from a pregnant woman; the brain tissue of two stillborn babies was tested and turned up positive for Zika. Working collaboratively, putting aside egos and individual accomplishment to solve a scientific puzzle and address a humanitarian crisis, the team established the Zika-microcephaly link in only three months.Recruiting 1,000 pregnant women with Zika symptom to participate in a larger study, Dr. Turchi and her team ultimately published their results in the British medical journal The Lancet. Dr. Turchi was named one of the ten most important scientists of 2016 by the science journal, Nature, and made TIME magazine’s “100 Most Influential People” issue of that year.Today, working urgently, new research collaborations help drive the development of vaccines and cures that stop the spread of Zika and end Zika-related microcephaly.I have learned a lot from researchers like Dr. Janssen, Dr. Tuchi and my partners at Johnson & Johnson. Namely that the impossible is not only achievable – it is achievable much faster than you might believe.When you know that people are dependent on you to make change fast, when you have a noble aim and a big audacious goal and – most importantly – when you bring together the right partners, innovation can happen very quickly. A great example of this is around Ebola, when researchers and companies including Johnson & Johnson developed and delivered millions of doses of vaccine in an incredibly short period of time, which could be used in the event that the virus was not able to be contained.In Dr. Turchi’s case, while following the highest scientific standards, she spoke about the suffering she saw in the most human terms. That humanity, and the mission to end suffering, drove her team’s superhuman effort and produced life-changing scientific progress.
ShareShare Wonder Women: Celebrating Female Heroes of STEMLikeWonder Women: Celebrating Female Heroes of STEMCommentShareShare Wonder Women: Celebrating Female Heroes of STEMFollowSeema KumarSeema KumarVice President, Innovation, Global Health, and Policy
April 21st 2017
Why the Menace of Mosquitoes Will Only Get Worse
Climate change is altering the environment in ways that increase the potential for viruses like Zika.
BY MARYN MCKENNAAPRIL 20, 2017
The outbreak began so slowly that no one in Dallas perceived it at first. In June 2012, a trickle of people began showing up in emergency rooms broiling with fever, complaining that their necks were stiff and that bright lights hurt their eyes. The numbers were initially small; but by the middle of July, there were more than 50 victims each week, slumping in doctors’ offices or carried into hospitals comatose or paralyzed from inflammation in their brains. In early August, after nine people died, Dallas County declared a state of emergency: It was caught in an epidemic of what turned out to be West Nile virus, the worst ever experienced by a city in the United States. By the end of the year, 1,162 people had tested positive for the mosquito-borne virus; 216 had become sick enough to be hospitalized; and 19 were dead.
West Nile was not new to the United States. It had been a minor summer threat since August 1999, when it made 17 people sick in New York City. That was the virus’s first entry into the country, and it expanded through it thereafter. It landed in Dallas in 2002, sickening 202 people and killing 13. When it moved on toward the West Coast, epidemiologists in the city thought West Nile would no longer be a threat. And events seemed to prove them right: Each year, there were just a handful of cases. In 2011, the year before the epidemic, there was only one.
“We all thought these things come as a flash in the pan: one big outbreak and then you don’t see them again,” Dr. Robert Haley says. Haley is the director of epidemiology at the University of Texas Southwestern Medical Center in Dallas and a former disease detective at the C.D.C. After the last cases were recorded in the final days of 2012, he and a team of researchers studied the episode. Right away, they could see the geography of the illness: Victims were clustered in affluent ZIP codes where many owners had walked away from overmortgaged mansions. Haley and his team knew that there would be abandoned swimming pools and potted plants there — perfect places for mosquitoes to breed unbothered. But the financial crisis was four years old in 2012. The homes had been neglected for years without triggering an epidemic; no matter how many mosquitoes bred in the summer, the deep cold that blankets central Texas a dozen days every winter would knock the bugs down again.
Except, Haley remembered, it had not been very cold that year. There was only one night of hard frost; everyone had talked about it, grateful they did not have to dash out to wrap plants and turn off hose taps while thermometers plunged. The investigators downloaded federal weather data for each year since West Nile first arrived in Texas and plotted the metrics against the case counts. The epidemic year was an outlier on every measure, with the warmest winter, the warmest spring and the heaviest early rainfall in 10 years. It had been a freak weather event, and mosquitoes benefited from it. The insects survived the winter, so there were more of them to start with. They woke sooner, spilled out earlier from their winter hiding places and bit people in greater numbers than in any other year, transmitting so much virus that it made many people gravely ill.
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That Dallas’s unusual weather favored the growth of mosquitoes might seem like random bad luck. But Haley doesn’t think of it as an accident. He considers it a warning. Climate change is turning abnormal weather into a common occurrence: Last year was the warmest year on record, the third in a row, and there were more heat waves, freezes and storms in the United States that caused $1 billion or more in damage just in 2016 than in the years 1980 to 1984 combined. Anything that improves conditions for mosquitoes tips the scales for the diseases they carry as well: the West Nile virus that flattened Dallas, the dengue that returned to Florida in 2009 after 63 years and the newest arrival, Zika, which gained a toehold in the United States last year and is expected to surge this summer. “These aberrant years are becoming more common,” Haley told me. “Climate change is clearly altering the environment in ways that increase the potential for these diseases.”
When the health effects of climate change are discussed, the planet-scale impacts get the attention: rising temperatures, which can cause death from overheating; earlier springs, which pump more pollen toward the allergic; runoff from violent storms, which washes fecal bacteria out of sewer pipes; changing airflows that trap ozone near the ground, stressing the systems of people living with heart disease.
The unpredictable weather patterns stimulated by climate change affect infectious diseases, as well as chronic ones. Warmer weather encourages food-borne organisms like salmonella to multiply more rapidly, and warmer seas foster the growth of bacteria like Vibrio that make oysters unsafe to eat. Spikes in heat and humidity have less visible effects, too, changing the numbers and distribution of the insect intermediaries that carry diseases to people.
When former Vice President Al Gore spoke at a meeting on climate and health in Atlanta in February, he chose to start his talk not with a starving polar bear or a glacier falling into the sea, but with images of mosquitoes and ticks. “Climate change is tilting the balance, disrupting natural ecosystems and giving more of an advantage to microbes,” Gore said, standing in front of a giant image of Aedes aegypti, the mosquito species that transmits yellow fever and dengue, and now the Zika virus as well. “Changing climate conditions change the areas in which these diseases can take root and become endemic.”
Right now, yellow fever is causing an epidemic in South America, and dengue has been increasing in Central America. But in the United States, the most alarming disease linked to mosquitoes is Zika, which can cause devastating birth defects.
Zika has been a persistent concern since January 2016, when a Houston man became the mainland United States’ first case, arriving back from a trip to El Salvador with the fever, rash and red eyes of full-blown infection. Now more than 5,200 U.S. residents have come down with the virus, at least one in every state except Alaska. The vast majority were infected by being bitten outside the country, and a small number by having sex with someone who was infected that way. But more than 220 people have caught Zika from local mosquitoes carrying the virus. Almost all of those victims live near Miami, and six live in Brownsville, Tex., along the Mexican border. No one can say yet whether those clusters are random blips or early indications of a pattern of transmission that will blow up into an epidemic when the weather warms this year.
Aedes aegypti are present in more than half the states, from California to Florida and as far-flung as San Francisco, Kansas City and New Haven; entomologists have found that they regularly survive through the winter in sheltered spots in Washington, D.C. Unlike the salt-marsh mosquitoes that whine through beach towns at twilight or the night-biting Culex that carry West Nile between birds and humans, aegypti prefer proximity to people; we are their favorite meal. To get to us, they fly into houses and conceal themselves in closets and under beds and furniture. They have evolved to breed in the tiny pools of water we carelessly create around us: in an abandoned tire, the saucer under a houseplant, even an upturned bottle cap.
Like West Nile, Zika can cause high fevers and paralysis — but unlike West Nile, it can also trigger catastrophic birth defects in the children of women infected while they are pregnant. It appears to destroy brain tissue while a fetus is growing, causing the skull to collapse. It also seems to cause brain damage, and eye, ear and joint abnormalities later on — though what will happen to babies as they grow is uncertain, because all the children born to Zika-infected mothers are still toddlers. In the United States, the C.D.C. has identified that 1,311 women who were pregnant in the past year were possibly infected with Zika; 56 of their children were born with Zika-related birth defects. In seven cases, the pregnancies ended early, and the fetuses were shown to have been affected. The C.D.C. recently announced that nearly 10 percent of women infected while they were pregnant had a child with a birth defect — 15 percent if they were infected in their first trimester.
The combination of an ugly virus and a stealthy predator is unnerving — especially because in the year since that first Houston case, it has become clear that the United States is more vulnerable to Zika than anyone thought. Like generals basing their strategy on the last war they fought, public-health experts have set up their defenses based on what worked for previous threats. The traps that health departments bought to catch Culex mosquitoes are not attractive to Aedes. The spraying with pesticide by trucks and airplanes that knocks down nuisance mosquitoes cannot reach ones that have sneaked into buildings. The best defense against Aedes mosquitoes turns out to be not big municipal gestures but small individual actions: destroying their habitat by emptying the pools of water where they reproduce, and keeping them from eating by repairing windows screens and wearing bug repellent.
Those strategies require that landlords and municipal authorities pay attention to housing repairs and garbage pickup, and ask families who probably have other priorities to stay alert to conditions they did not cause. Since the start of the Zika epidemic, a few disease experts have been warning that the parts of the United States where Aedes mosquitoes flourish — the Gulf Coast, especially its largest cities — are also those that possess the worst poverty and municipal neglect, and that are particularly vulnerable to an outbreak.
‘Climate change takes a risk that already exists and enhances it.’
“That’s an invitation to Zika, right there,” said Dr. Peter Hotez, the founding dean of Houston’s National School of Tropical Medicine, as he glared at a heap of garbage in the city’s Fifth Ward, a historic — and historically neglected — black community northeast of downtown. The garbage was resting in a grass-lined ditch where a more northern city would have put a sidewalk, an old accommodation to Houston’s drenching afternoon thunderstorms. The ditch was damp, and so was the heap. There was a sodden mattress, a turned-over box spring, a pile of torn drywall, old tires and a dozen plastic bottles lying on their sides; there were scummy puddles caught in the tires and an inch of old rainwater in the soda bottles. The heap was stacked against a sign that said “No Dumping.”
We had driven past other piles, one every few blocks: lumber tossed on top of an old TV with the back torn off, Big Gulps and beer bottles spilling from contractor bags, a tumble of tires next to a “Fix Flat’s” sign. On the way into the neighborhood — seven miles but many tax brackets from Hotez’s new labs in the Texas Medical Center, the largest collection of medical schools and hospitals in the world — Hotez had said it was plagued by dumping. Scofflaws would offload trash when no one was watching, trusting that the neighborhood’s lack of political pull would keep them from being held accountable. It was clear the garbage infuriated him. In a colder city, it might have represented victimless cheating; in an area where the virus might land, it was a threat to mothers and children.
“We have no historical expertise in how to do Aedes aegypti control,” Hotez told me. “We’ve never done it, and now we’re playing catch-up in the middle of an epidemic.” He glared at the garbage again. “We have the perfect mix of factors here for Zika transmission to begin.”
Every new disease feels like a shock, an unpredicted emergency that we have to scramble to catch up to. But at this point in American history, mosquito-borne illnesses ought not to take us by surprise. The epidemics they created shaped the United States from before it was a country; repeatedly, over hundreds of years, they caused towns to empty in panic and ports and state borders to slam shut.
Yellow fever first arrived in 1693 with a boatload of British soldiers who sailed from Boston to attack the French-owned, sugar-producing island Martinique and caught the illness there. The return of the survivors — only 300 soldiers and 800 sailors, of the 4,200 who embarked — sparked an epidemic that sent residents fleeing to the countryside. In the summer of 1793, the fever was carried into Philadelphia by a merchant ship and killed more than 4,000 people, out of a population of roughly 40,000. In 1878, cargo barges moving up the Mississippi River from New Orleans took yellow fever to Memphis; 5,000 people died, and half the city evacuated to escape infection.
When settlements moved south, mosquitoes were waiting. In 1839, when Texas was a newly independent republic and Houston was briefly its capital, a captain rowed ashore at the island of Galveston, its main port. He was returning from a trade run down the Mexican coast, and his son was ill on board; he begged the port authorities to let him see a doctor. When they berthed and unloaded, the virus went with them; the son died, the father died and Galveston and then Houston were swamped by an epidemic of yellow fever. More than 200 people died, 12 percent of the new city’s population. (Later that year, the government relocated inland, to Austin.) In 1867, yellow fever came again, so hard that the island of Galveston was blockaded by boats outside the port and troops on the causeway to the mainland. “The fever is getting pretty bad indeed,” Thomas Seargeant, 26, who was Gen. Robert E. Lee’s attaché in the just-concluded Civil War, wrote to his sister Annie in Stanford, Ky., on Aug. 13 that year. “We had 24 buried on Saturday, about the same Sunday and today I fear it will be equally as fatal.” He was dead two weeks later.
In 1885, a ship from the Caribbean landed with mosquitoes bearing dengue, which used to be called “breakbone fever” for the severe joint pain it causes. It spread through Texas on the rail line that carried cargo inland; when it reached Austin, it sickened 16,000 people out of 22,000 living there. In 1935, malaria — carried by other mosquito species — sickened 25,000 people along the Texas coast, 1,500 just in Houston. Malaria was such a constant presence in the South, and its prostrating fevers so destructive to the productivity of farming and manufacturing, that when President Franklin Roosevelt created the Tennessee Valley Authority in 1933, its programs included malaria control among their priorities. When the United States entered World War II, the government created an Office of Malaria Control in War Areas to ensure boat and tank building would not be slowed down and soldiers in training would not be taken out of service. (Later it became the C.D.C.)
In the midst of that history, on the other side of the world, researchers in 1947 trapped and caged a feverish rhesus monkey outdoors in the Zika Forest in Uganda, part of a study looking for yellow fever. The researchers who were monitoring the monkeys injected a sample of the sick monkey’s blood into mice. The mice also got sick. The team harvested a pathogen from their brains — not yellow fever, the virus they expected, but something no one had seen before. They named it Zika. Since 1995, that virus has been stored in Galveston at the World Reference Center for Emerging Viruses and Arboviruses, which Dr. Robert Shope and Dr. Robert Tesh created at Yale University and then took south. In the collection, among the largest in the world, Zika was considered one of the least important samples. No agency had ever written a grant to study it.
Shope died in 2004. Three years later, Zika caused its first known outbreak, infecting three-quarters of the population of Yap, a remote island in the Pacific, and leaving almost a quarter with fever, rashes, red eyes and joint pain. Yap lies 500 miles from any population center, and no one could demonstrate how the virus landed there — but in 2013, it leapt east across thousands more miles, sickening an estimated 19,000 people in French Polynesia. And then it jumped again, landing in Brazil and igniting a worldwide epidemic in 2015, focusing attention for the first time not just on the orphan virus but also on the Galveston lab that harbored it.
Aedes aegypti.CreditAndrew Bettles for The New York Times
“Zika surprised everyone,” Tesh says. “Just as West Nile virus did. When West Nile came to the United States in 1999, we knew it had occurred in Africa and in the Middle East, but nobody thought of it as a serious problem. No one thought Zika would be of much significance either.”
Tesh, whom I met in a small office attached to his lab inside the University of Texas Medical Branch tower, spent much of his career hopscotching from the United States to developing nations, examining viruses in the places where they emerged. “When Aedes aegypti was introduced to Panama in the 1980s, they started a big campaign of control,” he told me. “They got all the school kids to go out and turn over containers. That worked for a year or two or three, and then people lose interest. The same thing happened here, when West Nile appeared in 2002. Everyone in Houston was very scared. They put out messages: Don’t go to the baseball game at night. Wear repellent. Wear long-sleeved shirts. Then, after a year or two or three, who doesn’t go out to watch the fireworks at night? Or a concert, or a baseball game? People forget.”
In the past century, according to the E.P.A., the average temperature in Texas has risen as much as one degree Fahrenheit — a noticeable twitch in a system that was stable for millenniums. Rainfall has increased in the central and eastern parts of the state, where most of the population resides. On the coast, the sea has risen nearly two inches per decade. Scientists have noticed the impact inland, too. “When I came to El Paso eight years ago, you had to look to find Aedes aegypti here,” Doug Watts, principal investigator at the University of Texas at El Paso’s Mosquito Ecology and Surveillance Laboratory, told me. “Now you find them in just about every backyard.”
The effects have rippled farther north as well. Since 1980, the amount of time when conditions are ideal for mosquitoes — more warmth, more humidity — have increased by five days in 125 American cities, according to the news and research organization Climate Central. In 10 cities, the mosquito season has grown by a month. In 21 cities — on the Atlantic Coast below Norfolk, Va.; in much of Florida; in Mobile, New Orleans, Beaumont outside Houston and south to Corpus Christi — mosquitoes are active at least 190 days per year. “Climate change is certainly expanding the geographic range of mosquito species, and inevitably the diseases follow them,” says Nikos Vasilakis, an associate professor at the University of Texas Medical Branch and a member of its Zika research effort. “But it also shortens what we call the extrinsic incubation period, the time it takes from when a mosquito takes a blood meal to when it becomes infectious. The standard is 14 days, but in warmer periods we can see it as short as nine or 10 days.”
If the impact of climate change on mosquitoes and the diseases they carry were predictable, anticipating what comes next might be simple. It is not. The perturbations that cause a moist early spring like the one Dallas had in 2012, favoring mosquito reproduction, can equally cause devastating floods — like the wall of water that swept through central Texas in May 2015 and killed 11 people — that will scour mosquito eggs from wherever they have been laid. Warming temperatures that allow mosquitoes to move north into new territory may also make their current territory inhospitable. In 2012, researchers at Texas Tech University estimated that in Chicago, rising temperatures would expand the length of the season for the mosquito that carries dengue — but in Atlanta and Lubbock, Texas Tech’s home turf, summers would become so hot and dry that the risk of transmission would shift to spring and fall, when residents would not be on guard. The unpredictability will increase the challenge of preparing for diseases whose incidence will also increase.
“Climate change is a threat multiplier,” Katharine Hayhoe, one of those researchers and a director of Texas Tech’s Climate Science Center, told me. “If there’s one overarching theme that connects almost every way that climate change impacts us, it’s that climate change takes a risk that already exists and enhances it. It’s not inventing something new. It’s taking something that we’ve already dealt with before, but giving it that extra oomph that makes it a bigger problem.”
One other factor complicates the calculation of how much of a threat mosquito-borne diseases pose, this summer and in years to come: the global movement of people. In its monthlong lifetime, an Aedes mosquito is unlikely to fly more than a quarter-mile from where it hatched. It is possible that an insect carrying the virus could fly into an airplane in one country, ride for thousands of miles and fly out into another; every few years, mosquitoes taking a trip like that cause clusters of what is called “airport malaria.” But it is much more likely that Zika will arrive in the bloodstream of an infected person, as yellow fever did in enslaved Africans in the 17th century and dengue in Caribbean traders in the 19th. Mosquitoes carry virus from one person to another, but it is the movement of those people — for pleasure or family ties or business, in flight from weather or strife — that transports it over borders and into new homes.
There is no city in the parts of the United States hospitable to Zika that embodies migration more than Houston does. Its reach to the Gulf of Mexico and halfway to Austin is borderless and porous, a jostling sprawl of people who arrive on direct flights from 30 other countries and through one of the busiest container ports in the United States. One-fourth of its residents were born somewhere else. Harris County, which surrounds it, has 4.5 million residents, who speak 145 languages and live in 34 municipalities on 1,778 square miles, an area larger than Rhode Island.
The possibility of locating the arrival of Zika in that complexity “is a needle in a haystack, times two,” Dr. Umair Shah says. The executive director of Houston’s Public Health Department, Shah is a physician from Cincinnati who studied philosophy as an undergraduate and speaks three languages.
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The shock of a new disease is almost always followed by vilification of the people who are believed to have carried it, from the Eastern European Jews blamed for cholera in 1890s New York to the health care workers forcibly quarantined because of Ebola fears. Shah’s own parents were immigrants from Pakistan. He is acutely conscious of how migration complicates preparing for diseases, and of the need to educate without assigning blame.
“There’s a narrative that people want to paint, that the reason this is happening to us is because an individual of Latin American origin comes into our country and gives us this disease,” he says. “But it could be a businessman who goes to a Zika-affected country, gets bitten, doesn’t know he has Zika because he doesn’t develop symptoms, comes home, doesn’t wear mosquito repellent while he’s here because he doesn’t know he is a risk, gets bitten again — and bam, it’s in our population.”
Of the two places that have experienced Zika in the United States, Miami has had the most illness, and by far the most attention. Its first local case, in Wynwood, a glossy entertainment district, was announced on July 29 last year and triggered an uproar of news conferences, congressional hearings and emergency spraying from airplanes before the virus ceased passing among local mosquitoes in early December. Brownsville’s outbreak was much quieter: a first case in November, a local woman who had not traveled anywhere outside the area, followed by five more, and by a C.D.C. warning for pregnant women to avoid the city.
But it is Brownsville, more than Miami, that highlights the ways in which Zika may take hold in the United States now, because in Brownsville, every factor that might encourage Zika already exists. The weather is semitropical and humid; on the day I arrived in March, it was 20 degrees warmer than Houston. Its residents have high rates of obesity and diabetes, conditions that undermine the body’s defenses against disease. It is one of the poorest cities in the country, and the housing is frequently substandard; one place where Zika surfaced began as a colonia, a formerly illegal subdivision started without city surveying or grading, with a history of ponding and bad drainage. And the city contains an untraceable churn of people. Mexico, which has higher rates of Zika infection, wraps around a large swath of Brownsville. Last year, the traffic across the area’s four border bridges included 46,395 bus passengers, 9.4 million car passengers and 2.6 million people on foot. “Asking ‘When did you travel?’ doesn’t mean anything,” says Esmeralda Guajardo, the health administrator for Cameron County, which includes Brownsville. Going back and forth daily is a way of life.
And like the rest of Texas, Brownsville has begun to experience the effects of climate change, along with a near-certainty that those will become more pronounced. A year ago, Kelly Neely, then a Texas Tech master’s student working with a colleague of Hayhoe’s, combined detailed door-to-door data on two neighborhoods in Brownsville with an array of greenhouse-gas-emission and climate-change forecasts to reach “an ensemble of potential realities,” she says. In most of her results (which have not yet been published), populations of mosquitoes rose and the overall season grew longer.
On the last afternoon I was in Brownsville, I took a drive with Arturo Rodriguez, the city’s public-health director. Mosquito-borne diseases are a constant presence in the city. There was a large outbreak of dengue in 2005, and last year a resident came down with Texas’ only locally acquired case of chikungunya. It has year-round mosquito-control workers, unusual for a relatively small community, and sprays and traps insects to be analyzed.
Rodriguez wanted me to perceive the difference between a political border and a barrier that could keep out disease. The border wall already exists in Brownsville, perched on a levee an irregular distance inland from the Rio Grande; in some neighborhoods, it slices through backyards. But at one spot in the city where Zika was found, the river is so narrow that Aedes mosquitoes could fly over. The virus would not have to rely on people to transport it, and the fence, an array of metal mesh and iron uprights, would not shut it out.
Rodriguez had just come from teaching a high school class about the dangers of Zika. The class was all girls, and they were all pregnant; the Brownsville Independent School District allows teenage mothers to transfer into an accelerated program to keep them from dropping out. He had reminded them that Zika is transmitted sexually and talked to them about the importance of wearing repellent and emptying drums of water and doing anything they could to protect their babies. He was not sure how much power the girls had in their households, though, and worried the message might not be heard.
Knowing that Zika was already in his city and coming across the border, I asked him whether he worried that a climate that is already warming would make his job harder. He thought for a minute and sighed. “I realize that there’s nothing I can do to change it,” he said. “The way I really think about it is, How can I diminish the impact? I try to live with my new reality, and to just keep hoping.”
Maryn McKenna is a senior fellow at the Schuster Institute for Investigative Journalism at Brandeis University.
Feb 08 2017 Zika Update
For many at Zika's epicenter, the struggle has just begun
RECIFE, Brazil — In this city at the heart of the Zika outbreak, the gloom and dread have lifted from maternity hospitals and delivery rooms.
The scary government posters with giant mosquitoes have mostly come down. Fertility clinics are busy again. At one public hospital that has delivered 1,700 newborns over the past five months, doctors haven’t seen a single case of Zika-related birth defects.
“It’s as if we’ve all forgotten about Zika,” said Erika Alcantara, 17 weeks pregnant, who had waited for the epidemic to pass before she and her husband tried for their second child.
A year after U.N. health officials declared Zika a global emergency, the city that produced some of the outbreak’s most terrifying and indelible images of badly deformed infants feels like a place that has mostly moved on.
But not everyone has bounced back so fast. Not the parents of the babies in those heartbreaking photographs.
Initially, many feared that the infants would be merely the first wave of Zika victims, with many more to follow. Yet as the virus spread across the Americas and infected hundreds of thousands, it did not inflict the kind of damage seen here in northeast Brazil, where three-quarters of Zika-related birth defects have been reported.
Today those families are like the survivors of a natural disaster. Though Zika scared a lot of people, its lasting harm fell on a relative few.
Those families have developed new routines. Eliane Paz ferries her son, Davi Lucas, to five different hospitals a week for visual, motor and auditory therapy. The 1-year-old was diagnosed with severe microcephaly when he was born in October 2015, weeks before doctors connected the condition to Zika. Paz, a former maid, wakes up at 4 a.m. to make the 90-minute journey to the rehabilitation centers where specialists work with her son.
Recife’s rehab clinics are crowded with children who have microcephaly, a congenital condition defined by undersize heads and impaired cognition. Now toddlers, they struggle to swallow, roll over or simply hold up their heads. Many languish in a semi-vegetative state.
Their parents say they live for milestones that others take for granted. When their children learn to smile, laugh or grip items, it’s just enough to stave off the despair.
At Davi Lucas’s motor therapy appointment, doctors insert cold bits of papaya into his mouth and stroke his cheeks to try to stimulate chewing. The mashed fruit mostly falls out. For months after he was born, the boy cried constantly, his mother said, but he wasn’t able to produce tears.
“The day he shed his first tear, I started crying, too,” Paz said. Having quit her cleaning job, she receives a $300 monthly stipend from the government and devotes all of her time to the boy. It stings when strangers stare at his deformity or she overhears their comments: “Mosquito Boy.” “Devil’s child.”
Sixty families come for treatment to the IMIP public hospital’s clinic, the largest rehabilitation center in Recife for children with microcephaly. There are 40 more children on a waiting list. The demand for exams has stretched wait times for appointments from a few weeks to several months, and even the families who are grateful to receive care say it isn’t enough.
Multiple medications have stopped Davi Lucas’s seizures, but he needs a chest scan to determine why he’s having breathing problems, and the machine at the hospital is broken. His mother worries that public attention is fading as Zika infections ebb. “What’s going to happen to us when people forget about Zika?” Paz asked.
A year ago Zika was spreading rapidly across the Americas, prompting governments to warn women to avoid or postpone pregnancy. Today Zika is waning virtually everywhere in the Western Hemisphere. Epidemiologists say the pattern fits the typical trajectory of a virus that spreads explosively at first but fizzles out as it runs out of new hosts to infect.
What researchers still don’t understand is why the majority of Zika-related birth defects have been so concentrated in one region of a single country.
Of the more than 2,600 cases of Zika-related congenital syndrome confirmed so far in the Americas, nearly 2,400 are in Brazil. The vast majority are in a cluster of northeastern states, including Pernambuco, where Recife is located.
“Why was there so much microcephaly if it’s the same virus?” said Amilcar Tanuri, an epidemiologist at Federal University of Rio de Janeiro who formerly worked for the Centers for Disease Control and Prevention. “We’re looking at other possible co-factors, but we’re still in the middle of the investigation,” he said.
With its heat, abundant mosquitoes and extensive slums, Recife, the largest urban area in Brazil’s northeast, became one of Zika’s most potent launchpads. The city and surrounding state typically register 11 or 12 cases a year of microcephaly, but by late 2015, hospitals were reporting 50 to 60 a month. “It was a tsunami,” said Sergio Negromonte, the director of the maternity ward at one of the city’s largest private hospitals.
His hospital’s emergency room shut down because patients with Zika symptoms were spilling out into the hallways and parking lots. Sonogram exams became somber, fateful appointments — “like a sentencing,” said Pedro Pires, an obstetrician-gynecologist who specializes in Zika.
State health records show that 2015 was a peak year for births in Pernambuco, precisely at the moment when Zika was most virulent but had yet to be identified.
As much as 70 percent of Recife’s inhabitants contracted Zika in 2015 and 2016, according to Pires, and that high rate of infection likely prevented a revival of the epidemic in recent months — summer in the Southern Hemisphere — because most of the population has become immune.
Last year, the birthrate fell by about 7 percent statewide, according to the latest figures, but it dropped as much as 45 percent at the private clinics that cater to more affluent women. Negromonte and other doctors say they have never seen such a sharp drop in birthrates.
The panic has mostly lifted. Alcantara, the mother who delayed pregnancy because of Zika, said she and her husband, Wilton, made that decision after the couple and their 3-year-old daughter, Lara, were infected in early 2015.
But new research on the disease and its virtual disappearance convinced Wilton, himself an emergency room doctor, that it was safe enough to have a child in Recife again.
The couple brought Lara with them on a recent morning to a routine sonogram check. It showed a healthy baby boy. The only tears were Lara’s. She wanted a sister.
Her father hugged her, laughing. “We’ll try for another girl next year,” he said.
Gleyse Kelly da Silva had never heard of microcephaly when her unborn daughter was diagnosed with it in late 2015. “I was shocked by what I saw on Google,” she said. “I would cry myself to sleep every night, and when my husband thought I was no longer awake, he would start crying.”
The hopelessness gave way to action. A few months after her daughter Giovanna was born, she formed a WhatsApp chat group for mothers of children with microcephaly. Within a week, the group had 100 members. What started out as a way to share tips on treatment facilities and navigating the bureaucracy became a source of 24-hour support.
When her daughter kept her up all night crying, da Silva would turn to the group and find other mothers also awake. “They would tell me, you’ve got this, keep going,” she said.
Today, 400 mothers from across the state have joined the chat group. It has become their best megaphone whenever they need to amplify pressure on government health officials. And when one mother is tight on cash and can’t afford medicine, others step in to help. They share tips on which anti-seizure drugs work best and which sleeping positions can soothe inconsolable babies.
“I joke that we’ve all become doctors without diplomas,” said da Silva, 28.
Giovanna, now 15 months old, is still unable to hold up her head for long. She eats better now but doesn’t sleep much. At night, da Silva and her husband, Felipe, settle onto the couch with the baby. She doesn’t cry if her father keeps her bouncing on his knee.
He has had to quit his job as a security guard. But he has learned to sleep this way: head slumped into the armrest, television on mute, with Giovanna draped across his leg, bouncing, bouncing, bouncing.
The Long Fight Against Zika
According to the World Health Organization, Zika is no longer classified as an international public health emergency. “We are not downgrading the importance of Zika,” explained Pete Salama, executive director of WHO’s health emergencies program, to Science. “By placing it as a longer-term program of work, we are saying Zika is here to stay.” Good news, then, that a proposal to release genetically engineered mosquitoes in Florida to fight the virus has finally been given the green light. The initiative received a mixed response when put to public vote on election day, but mosquito control officials in Florida have decided to start the trial. Meanwhile, the New York Times reports that the quest to find a vaccine for the virus continues. The good news is that researchers are confident that they can make one; the bad news is that nobody knows how long it will take to find one that's reliable. Clearly, the WHO realizes that this could take some time.
BANGKOK, 5 October 2016 (NNT) – According to the Ministry of Public Health, the number of Zika patients in Thailand has accumulated to almost 400 so far while a third baby with microcephaly has been found.
Dr Jessada Chokdamrongsuk, Director-General of the Department of Disease Control, reported that the country has recorded a total of 392 cases of Zika, 36 of them were found in pregnant women. Nine of the pregnant patients have already given birth to their babies while two of the babies have been diagnosed with microcephaly, a birth defect caused by the Zika virus.
In the latest development, an unborn baby of a Zika-infected mother has been confirmed by an ultrasound scan to have microcephaly. After birth, doctors will conduct examinations to determine whether or not the baby’s small head size has any connection with Zika.
Dr Jessada stated that the Public Health Ministry already has measures in place to take care of pregnant women infected with the Zika virus. Should their child be born with microcephaly, health officials will closely provide them with assistance, along with constant developmental checkups on the baby for the first two years of birth.
Oct 3rd 2016
Here is an inspiring little video that I thought you might like
From bad to much worse: Not only are locally-acquired Zika cases growing in Florida, but 84 pregnant women have tested positive for the virus in the state, including at least 15 who've already given birth, say health officials. It isn't clear how many of those pregnancies had complications, but doctors have confirmed that a baby was born with microcephaly at Jackson Memorial Hospital in Miami, reportsWPLG. Excluding the pregnant women, officials say 56 people have contracted the virus in Florida, mostly in Miami-Dade County, per WJXT. There are another 604 travel-related cases in the state. "Zika is a thing. Zika is real, and while we don't understand it fully, that is not a reason to dismiss its impact," says a local doctor.
BANGKOK - The number of detected Zika infections in Thailand has jumped significantly this year compared to recent years.
The number of detected Zika infections in Thailand has jumped significantly this year compared to recent years. Between 2012 and 2015, an average of just five people were recorded as infected with the Zika virus each year.
But in the first six months of this year, at least 97 people in Thailand have been diagnosed with the disease. And over the past week, new infections have been detected in Chiang Mai, Chanthaburi, Phetchabun and Bung Kan provinces.
THE FIRST CASE of a mosquito giving Zika to someone in the US was always going to be a matter of when, not if. That “when” may be now. The Florida Department of Public Health announced late yesterday that it is investigating a case of non-travel related Zika in Miami-Dade County, at the very southeastern tip of the state.
A key part of the investigation will be testing if mosquitoes around the patient’s home carry Zika. The county had set out a type of mosquito trap, baited with carbon dioxide, that preferentially attracts the Zika-carrying mosquito species:Aedes egypti and Aedes albopictus. It’s now sent those mosquitoes to a lab at Florida Gulf Coast University to look for Zika virus. “We don’t have any results to report yet,” says Sharon Irsen, who co-leads the Florida Gulf Coast University lab with Scott Michael.
The university lab had been testing Miami-Dade’s mosquitoes for other tropical viruses, like dengue and yellow fever, for the past several years. Earlier this summer, they added Zika virus to their repertoire. The protocol is similar. “The mosquitoes are shipped in vials. We homogenize—basically mush up the mosquitoes—and extract the genome,” says Isern. Then they look for Zika’s genetic signature. The whole process takes about a week, but can go faster if necessary.
The Florida Department of Public Health did not specifically rule out sexual transmission of Zika and did not provide any additional details about the case. But sexual transmission is generally easier to prove, as long as you can test the partner. When Dallas found the first case of sexual transmission in the US back in February, they came out and said it. This week also saw a mysterious Zika case in Utah, which does not appear to be associated with mosquitoes, travel, or sexual contact.
If the Zika case in Miami-Dade is indeed traced back to local mosquitoes, it could herald more endemic infections to come. “It’s not a small story,” says Michael. “The mosquitoes that can transmit are all up and down the east coast and the Gulf coast.” Still, it is unlikely to ignite a full-blown epidemic like that seen in Brazil. Take the case of dengue, a similar virus spread by the same mosquito species that spread Zika. Florida has seen sporadic breakouts of dengue, but public health officials were able to contain them by containing the insects.
Zika has made residents more wary of mosquitoes. Miami-Dade county’s mosquito control has responded to 5,549 mosquito control requests from residents between October and July 7, compared to 4,408 for all of the previous year, according to county spokesperson Gayle Love. When mosquito control gets these requests, officials go out to drain any small pools of standing water in yards and spray bigger ones with larvicide. They’ll also check a few neighboring yards, because the Aedes mosquitoes can only fly so far.
This has been, and will continue to be, the core strategy behind containing Zika. The best way to prevent mosquitoes from transmitting Zika is to prevent mosquitoes in the first place.
Rio? No thanks, I'll watch the tele.
SALT LAKE CITY (AP) — A person infected with Zika has died in Utah, and while the exact cause is unclear, authorities said Friday it marks the first death related to the virus in the continental U.S.
The unidentified Salt Lake County resident contracted the virus while traveling abroad to an area with a Zika outbreak, health officials said.
The patient who died in late June was elderly and also suffered from another health condition, according to the Salt Lake County Health Department.
The person had Zika symptoms — including rash, fever and conjunctivitis — but it's unclear if or how the virus contributed to the death, said Centers for Disease Control and Prevention spokesman Benjamin Haynes.
Officials discovered the case while reviewing death certificates, and lab tests confirmed their suspicions, said Gary Edwards, executive director of the Salt Lake County Health Department.
Utah authorities refused to release additional information about the patient or where he or she traveled, citing health privacy laws.
The virus causes only a mild illness in most people. But during recent outbreaks in Latin America, scientists discovered that infection during pregnancy has led to severe brain-related birth defects.
It's spread mainly through the bite of a tropical mosquito.
No cases of locally transmitted, mosquito-borne Zika have been reported in the continental United States, according to The Centers for Disease Control and Prevention.
But a 70-year-old man from the San Juan metro area in the U.S. territory of Puerto Rico died in late February. Officials said he recovered from initial Zika symptoms, but then developed a condition in which antibodies that formed in reaction to the Zika infection started attacking blood platelet cells. He died after suffering internal bleeding.
More than 1,100 Zika illnesses have been reported in the 50 states and the District of Columbia, including six in Salt Lake County, according to health officials.
Almost all were people who had traveled to Zika outbreak countries and caught the virus there.
But 14 were people who had not traveled to Zika zones but had sex with someone who had.
The CDC has also been tracking pregnant women infected with Zika, and says they have five reports of pregnancy losses because of miscarriage, stillbirth or abortion.
This is not necessarily the advice from buzcall
do not take risks with your health.
It's not a big issue. You've got to come, you can come, enjoy..."
RIO DE JANEIRO: -- With this year’s Olympic Games just around the corner, Rio de Janeiro’s mayor is trying to dampen down fears over the Zika virus.
Eduardo Paes says visitors to the global sporting spectacle will be safe.
But health officials disagree, saying the mosquito-born virus does pose a threat.
“It’s not a big issue. You’ve got to come, you can come, enjoy – it’s the time of the year that’s the, it’s our winter and it’s never cold,” said Paes.
“And I know the British, they will love Rio as they did in the (football) World Cup.”
According to scientific evidence, Zika can can cause birth defects in newborns.
One expectant mother said she knows people with the virus.
“There are people with Zika everywhere – in my building, at my work, in my family. We know several and we’re a few kilometres from the Olympic park,” said Michele Camargo Moraes.
“It’s impossible the mayor doesn’t know anyone who’s had it. We don’t have any proof we can be calm.”
According to reports, US scientists have cloned the Zika virus, amid frantic efforts to develop a vaccine.
But a jab seems a long way off and pregnant women are being advised against travelling to infected areas.
BANGKOK: -- The Mahidol University has now achieved a breakthrough in
the birth control of the Aedes mosquitoes and will release the sterilized
mosquitoes into the real environment in Chachoengsao province for test.
Chief of the university’s Centre of Excellence for Vectors and Vector-Borne Diseases Vice Professor Pattamaporn Kittayapong said the mosquitoes sterilised via this two-step sterilisation technique will not affect the balance of nature because they will die within two to three weeks.
According to The Nation, they will mate with females in the wild and make the females sterile as well.
100 sterilised mosquitoes per household will be released into the nature for the first time at a pilot 150-household community in Tambon Hua Samrong of Chachoengsao’s Plaeng Yao district by the end of this month, she said.
The two-step method applies both X-ray technology and injection of Wolbachia bacteria which will help ease the number of patients suffering from dengue fever, Chikungunya, Zika fever and yellow fever.
The test release will be followed up for six months and if proved effective, a plan to set up a farm for Aedes mosquito sterilisation will be pushed forward in the hope of exterminating its population in nature.
There is concern that hundreds of thousands of people on the US island territory of Puerto Rico could become infected with the Zika virus this year.
Warmer temperatures and rising mosquito populations are expected to bring the virus to southern US states within weeks.
US health officials met in Atlanta, Georgia on Friday at a conference hosted by the US Center for Disease Control and Prevention (CDC) to devise a plan to tackle the virus.
“The frontline of the battle against Zika in the US is Puerto Rico. And we are very concerned that Puerto Rico could have hundreds of thousands of Zika infections and potentially thousands of pregnant women infected with Zika," said CDC Director Dr Tom Frieden.
He added in an interview that Puerto Rico had neither good surveillance nor good control measures.
In its latest report, Puerto Rico’s health department said there were 350 confirmed cases of Zika infection, including 40 pregnant women.
The “World Health Organisation declared a global health emergency’:http://www.who.int/e.../zika-virus/en/ in February because of evidence that Zika can cause microcephaly, a rare birth defect defined by an unusually small head. In adults, the virus has been linked to the typically rare autoimmune disorder, Guillain-Barre syndrome.
First detected in Brazil, the virus is growing throughout the Americas.
Poverty and recession are hampering the response in Puerto Rico, where mosquitoes have already caused repeated outbreaks of dengue and more recently, chikungunya.
If you need the early history please ask.